Toxicokinetics of Metformin During Hemodialysis

نویسندگان

  • Paul Ayoub
  • Pierre-Olivier Hétu
  • Monique Cormier
  • Alexandre Benoit
  • Andrea Palumbo
  • Marie-Claude Dubé
  • Sophie Gosselin
  • Marc Ghannoum
چکیده

To the Editor: Metformin-associated lactic acidosis (MALA) following metformin overdose or reduced metformin clearance in the setting of acute kidney injury is associated with high mortality. For most severe cases, current guidelines recommend hemodialysis (HD) to correct acidosis and associated electrolyte abnormalities, although its effect on metformin removal is considered uncertain. We report a case of severe MALA treated with HD.

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عنوان ژورنال:

دوره 2  شماره 

صفحات  -

تاریخ انتشار 2017